Glomerular filtration and saturable absorption of iohexol in the rat isolated perfused kidney
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چکیده
منابع مشابه
The Isolated Perfused Rat Kidney
1. In the isolated rat kidney, perfused at constant pressure with a medium free from renin substrate, addition of angiotensin I to the perfusate decreases renal 'plasma' flow. 2. A peptide inhibitor, SQ 20881, of converting enzyme reduces the vasoconstrictor effect of angiotensin I up to a maximum of 87%, the degree of inhibition being dose-dependent. 3. The molar ratio of equi-effective doses ...
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The perfused rat kidney was used for a study of gluconeogenesis. The kidney was completely isolated and perfused with Krebs-Henseleit bicarbonate buffer containing 5% albumin. Perfusion flow rate and pressure remained stable for 2 to 3 hours, although the glomerular filtration rate diminished with time. The fractional reabsorption of both water and sodium was 0.92 during the 1st hour of perfusi...
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Studies in experimental animals and humans have documented that inhibition of the renin-angiotensin system by angiotensin-converting enzyme inhibitors reduces urinary protein excretion rate and retards the development of renal injury. Here we sought to investigate whether angiotensin II (All) modified the size-selective properties to macromolecules of the glomerular capillary barrier in isolate...
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Nephrotoxicity is an important limitation to the clinical use of colistin against Pseudomonas aeruginosa and other gram-negative pathogens. Previous work reported net tubular reabsorption of colistin by the kidney in vivo, but there is no knowledge of its disposition within the kidney. This study investigated the renal disposition and potential transport mechanisms of colistin in the isolated p...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1996
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1996.tb15677.x